Hiring company: Takeda
Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist in our Process Chemistry Development department located at our San Diego, CA office.
At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and by being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster a diverse, equitable, inclusive, and collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission.
Pharmaceutical Sciences empowers innovative and flexible teams to enable fast global patient access to high quality products through a collaborative, data driven culture that develops and applies adaptive, forward-thinking technologies into predictive and sustainable solutions across a diverse pipeline. As part of Pharmaceutical Sciences, Process Chemistry Development (PCD) at the Takeda San Diego site is responsible for advancing novel synthetic molecule pharmaceuticals through the pre-clinical stage into early clinical development while operating in a highly dynamic environment with rapidly changing priorities. Key objectives will be development of robust, safe, and scalable processes for the manufacture of such pharmaceuticals in a fit-for-purpose manner, along with methods for achieving and controlling high standards of purity and quality.
POSITION ACCOUNTABILITIES:
- Designs scalable synthetic routes, solves synthetic chemistry problems.
- Analyzes and interprets scientific data independently.
- Designs strategies for reaction optimization, scale-up demonstration, and conducts troubleshooting experiments to achieve project goals.
- Develops strategies and independently executes on the plan for preparation of gram to kilogram quantities of APIs, intermediates, impurities, reference standards, and/or provides assistance towards management of such activities at our external CDMOs.
- Maintains a current understanding of the organic chemistry literature and technology trends/advancements.
- As necessary, prepares experimental procedures for patent applications and scientific reports as well as tech transfer documents in support of collaborations with Takeda’s external vendors (CDMOs).
- Actively builds the necessary cross-functional and cross-site relationships in support of early-stage Pharmaceutical Sciences development.
- Serves as a subject matter expert and collaborates with other Pharmaceutical Sciences functions (Analytical Development, Drug Product Development, etc.) in support of the development and implementation of an overall CMC strategy.
- May lead all or part of the PCD efforts on a program, represent PCD in cross-functional meetings, and correspond with multiple CDMOs.
- Attends and actively participates in Pharmaceutical Sciences Team meetings as a subject matter expert; presents results and process chemistry related matters; supports the development of CMC timelines; manages process chemistry related activities.
- Establishes metrics and has accountability for progress against project goals; regularly determines research project deadlines and objectives.
Education and Experience:
- A Ph.D. degree (strongly preferred) in organic chemistry with a focus on total synthesis or methodology development and 0-5 years pharmaceutical industry experience; an MS degree with 8-11 years of pharmaceutical industry experience; or a BS degree with 15+ years of pharmaceutical industry experience.
- A solid understanding of synthetic organic chemistry and route design (retrosynthetic analysis) with excellent laboratory and productivity skills
- Thorough experience in synthesis, purification, and characterization of complex organic molecules using the latest techniques.
- A high level of proficiency carrying out multi-step syntheses.
- Experience with process research/synthetic route scouting as well as process development is considered a plus.
- Experience in the use of technologies (e.g. flow chemistry, photo redox chemistry, Process Analytical Technologies (PAT) such as FT-IR, NIR, FBRM, UV-vis, etc., automation, artificial intelligence, kinetic modeling, etc.) and an interest in application to early development is considered a plus.
- Familiarity with cGMP production and regulatory requirements is considered a plus.
- Experience introducing synthetic/manufacturing technologies into a GMP setting and working in a multi-disciplinary team is considered a plus.
- Excellent communication and multitasking skills
Knowledge and Skills:
- Analytical and Problem-Solving Skills – Ability to troubleshoot critical issues or problems using appropriate information and determine causes and possible solutions.
- Teamwork – Builds a collaborative network of relationships with people in a variety of functions and roles, and leverages formal and informal networks to accomplish goals. Promotes shared responsibility for getting things accomplished across our organization.
- Communication Skills – Ability to expresses oneself clearly and concisely within team; documents issues and/or concerns concisely with colleagues; adjusts communication style as appropriate for the audience; proactively and effectively communicates with stakeholders and management; technical writing skills to support authorship and approval of internal technical documents
- Technical – Subject matter expertise in a specific scientific area or areas of organic synthesis.
- Resource Management – Ability to manage timelines as well as individual, departmental, and project goals; effective management of internal and external resources (CDMOs)
- Leadership Skills – Identifies opportunities and demonstrates initiative towards the accomplishment of department/function goals and objectives.
TRAVEL REQUIREMENTS
- Some domestic and international travel may be necessary
- Ability to travel to meetings or external vendor/CDMO sites, including overnight trips
- Requires less than 10% travel
WHAT TAKEDA CAN OFFER YOU:
- 401(k) with company match and Annual Retirement Contribution Plan
- Tuition reimbursement
- Company match of charitable contributions
- Health & Wellness programs including onsite flu shots and health screenings
- Generous time off for vacation and the option to purchase additional vacation days
- Community Outreach Programs
Effective November 1, 2021, absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.
Empowering Our People to Shine
Discover more at takedajobs.com
This job posting excludes CO applicants.
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EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.